The Agilent 6546 LC-QTOF mass spectrometer was acquired through a prestigious NIH S10 Basic Instrumentation Grant (BIG) (1S10OD036264-01A1), the first of its kind at Auburn University. This transformative investment strengthens Auburn’s research infrastructure, enabling advanced mass spectrometry capabilities that will accelerate biomedical research and enhance competitiveness for future NIH funding.
The instrument’s high resolution, superior mass accuracy, and low detection limits empower a wide range of applications, from cancer and neuroscience to drug discovery and botanical safety studies.
Our mission is to provide researchers with cutting-edge analytical tools for accurate mass measurement, structural elucidation, and comprehensive profiling of small molecules, peptides, and complex mixtures. The use of Agilent 6546 QTOF system, we aim to advance biomedical research in critical areas such as cancer, neuroscience, drug discovery, and the quality and safety of botanical dietary supplements, fostering innovation across Auburn University and beyond.
The Agilent 6546 QTOF system is available to all Auburn University investigators (NIH-funded major users, minor users, and new users) and external collaborators on a fee-for-service basis. The funding sources that we will prioritize are NIH (R01, R21, R15, R03, R44/R43, R41/42, R61), NSF, DOD, USDA, other federal Agencies, foundations, and private agencies. We provide consultation for experimental design and grant preparation, along with letters of support for proposals.
Agilent 6546 LC-QTOF System with 1260 Infinity II UHPLC:
Capabilities:
Software:
MassHunter Acquisition, MassHunter Qualitative and Quantitative Analysis, Masshunter Explorer, Lipid Annotator, and BioConfirm for peptide mapping and structural analysis.
Sample Preparation:
Our facility will be receiving a comprehensive range of samples for LC-QTOF analysis. To ensure optimal processing of samples by investigators, we will discuss and devise the best approach for each sample to facilitate efficient preparation of biological, botanical, and synthetic samples, thereby achieving accurate and reproducible results.
Suitable Analytes
The Agilent 6546 QTOF system supports a wide variety of analytes, making it ideal for diverse research applications:
Currently estimated pending final University approvals. Please contact HCOP Mass Spec hcopmassspec@auburn.edu to discuss projects
Each publication, press release, or other document about research supported by an NIH award must include an acknowledgment of NIH award support and a disclaimer such as “Research reported in this publication was supported by the Office Of The Director, National Institutes Of Health under Award Number S10OD036264. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.” Prior to issuing a press release concerning the outcome of this research, please notify the Office of Research Infrastructure Programs (ORIP) in advance to allow for coordination.
HCOP Mass Spec Email: hcopmassspec@auburn.edu
Principal Investigator
Angela I. Calderón, Ph.D., B.S. Pharm
Gilliland Professor, Department of Drug Discovery and Development
Harrison College of Pharmacy
Phone: 334-844-8333
Mobile: 334-703-9569
Fax: 334-844-8331
Email: aic0001@auburn.edu
HCOP Business and Fiscal Administration Office
Phone: 334-844-8365
Email: dealsam@auburn.edu
Instrumentation Manager/Operator
Zarna Raichura
Ph.D. candidate- Pharmaceutical Sciences| Medicinal Chemistry| Calderón Lab
Department of Drug Discovery and Development, Harrison College of Pharmacy
Email: zzr0009@auburn.edu
Mobile: 334-559-4494